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Chronically elevated blood glucose levels trigger a biochemical cascade that permanently stiffens your heart and arteries This happens through the formation of advanced glycation end products (AGEs), which cross-link with collagen in your vascular and myocardial tissues, leaving them rigid and unyielding This rigidity reduces arterial compliance and heart function, changes that can’t be undone This is why keeping HbA1c (a long-term marker for blood glucose levels) below 5% is critical for long-t
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Steps Involved in the Coagulation Cascade 1. Vascular Injury: Blood vessel damage triggers the cascade. 2. Platelet Plug Formation: Platelets adhere to the injury site, forming a temporary plug. 3. Activation of Clotting Factors: - Intrinsic Pathway: Activated by trauma inside the vascular system (slow, complex). - Extrinsic Pathway: Triggered by external trauma (fast, simpler). 4. Common Pathway: Both pathways converge, activating Factor X. 5. Thrombin Formation: Factor X converts prothrombin i
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