Background: The anti-folate drug methotrexate (MTX) is commonly used to treat rheumatoid arthritis. Objective: To determine the allele frequencies of five common coding single-nucleotide polymorphisms ...

Researchers have developed the first comprehensive atlas of allele-specific DNA methylation across 39 human cell types, revealing a complex landscape of epigenetic regulation. The study identified ...

ALFRED Revival is an open-source project to rebuild the allele frequency database created and hosted by the Kidd Lab at Yale University. Due to a lack of ongoing support for the project, the original ...

Owen Johnson receives funding from the Breakthrough Prize Foundation. Is there life beyond Earth? The question has turned out to be one of the hardest to answer in science. Despite the seemingly ...

In the world of genetics, understanding allele frequencies is essential for scientists and researchers. Allele frequencies provide insights into the diversity of a population and can help predict how ...

A major focus of human genetics is to identify severely pathogenic variants, both to help diagnose patients and as an entry point into understanding disease mechanisms. To that end, it is often argued ...

Ancient genome sequencing technologies now provide the opportunity to study natural selection in unprecedented detail. Rather than making inferences from indirect footprints left by selection in ...

Background: Lack of HLA data in southern African populations hampers disease association studies and our understanding of genetic diversity in these populations. We aimed to determine HLA diversity in ...

I've tried turning on and off downsampling - no effect. Oddly - setting allelle frequency threshold from 0.1 to 0.5 also had no effect. Setting it to 0.9 does remove the colored bars. I'll be ...

The word “frequency” alludes to how frequently something recurs. As an exercise, we could look at just some of the frequencies that the solar system can display. The sun emits electromagnetic ...

Allele Biotechnology said Pfizer, BioNTech misused protein in vaccine development Pfizer denied claims, said patent was invalid Parties said resolution was "mutually satisfactory" (Reuters) - San ...