The EMBO Journal10d
Nuclear PD-L1 triggers tumour-associated inflammation upon DNA damage
PD-L1 not only responds to the cGAS-STING pathway upon DNA damage, but also regulates cGAS-STING to induce inflammation. This ...
The EMBO Journal3d
Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease
This study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the ...
The EMBO Journal4d
Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors
This month's cover highlights the article JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia by Karoline Strobl, Maria Sibilia, Thomas Bauer and ...
The EMBO Journal7d
RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Small GTPase RHEB is a well-known mTORC1 ...
The EMBO Journal4d
Oncolytic viruses expressing MATEs facilitate target-independent T-cell activation in tumors
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oncolytic adenoviruses were designed to reach ...
The EMBO Journal7d
Developmental beta-cell death orchestrates the islet’s inflammatory milieu by regulating immune system crosstalk
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. While pancreatic beta-cell proliferation has ...
The EMBO Journal4d
OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancer cells often display centrosome ...
The EMBO Journal7d
Two FAM134B isoforms differentially regulate ER dynamics during myogenesis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Endoplasmic reticulum (ER) plasticity and ...
The EMBO Journal4d
Acidic pH can attenuate immune killing through inactivation of perforin
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cytotoxic lymphocytes are crucial to our ...
The EMBO Journal4d
CRISPR-Enabled Autonomous Transposable Element (CREATE) for RNA-based gene editing and delivery
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. To address a wide range of genetic diseases, ...