Stop the Spread. Injecting saline into mouse kidneys did not affect the left or right substantia nigra (top). Injecting fibrils of α-synuclein ablated about half of the dopaminergic neurons (middle ...

Sphere of Influence. In iAssembloids, microglia (red) form projections (white arrows), while astrocytes (green) assume star shapes typically found in the brain. [Courtesy of Kampmann et al., 2025.] ...

The Amyloid—Tangle Connection. Aβ aggregates (green) hyper-excite neurons in tau epicenters and connected regions, strengthening that connectivity. This pushes tau propagation from one region to ...

EBP1 is low in Alzheimer’s disease brains, hinting at human relevance. “Our study suggests that … preservation of functional EBP1 could be a therapeutic strategy for AD,” the authors noted. The ...

Alberto Cifelli, M.D., D.Phil. (Oxon), FCRP (London) Queen's Hospital, United Kingdom ...

Ph.D. in Biochemistry 2000, Umeå universitet.

Lactylation is a reversible, covalent, post-translational modification of proteins. It happens exclusively on lysine residues, where it influences protein structure, stability, localization, and ...

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Butovsky believes xenon has potential as an AD treatment. A Phase 1 clinical trial of xenon at BWH is recruiting healthy elderly volunteers to test safety and effects on immune cells. “I hope this ...