This mouse model was developed to investigate the effects of PINK1 deficiency (Kitada et al., 2007). The model involves a germline deletion of exons 4-7 of the endogenous Pink1 gene, creating ...

Changes in the choroid plexus and ventricles, visible on PET and MRI, suggest problems with waste clearance from the brain that might precede amyloid and tau accumulation.

If a person with no cognitive complaints tests positive for brain amyloid based on plasma p-tau217, what should their doctor tell them about their likelihood of getting Alzheimer’s disease? That’s the ...

Scientists have long known that people with cerebrovascular disease have higher odds of getting Alzheimer’s dementia. What has been harder to find is a good marker of brain vascular dysfunction that ...

The Alzheimer’s disease field has been abuzz about plasma p-tau217 for a while. This marker of brain amyloid can identify, with a high degree of accuracy, people with AD pathology among the ...

Professional Information Assistant ProfessorHarvard Medical School, Massachusetts General Hospital http://www.stantonlab.info Education Princeton University BSE ...

As awareness about dementia continues to grow worldwide, a spate of online courses aims to help both health professionals and the general public understand Alzheimer’s and related diseases. Below is a ...

These parkin knockout (KO) mice were generated by creating a germline disruption in the parkin gene within exon 3 leading to a truncated transcript coding for the first 95 amino acids of mouse parkin ...

Summary Two lines of transgenic mice that overexpress PSEN1 with the M146V mutation were developed simulataneously (line 8.2 and line 8.9) (Duff et al., 1996). Both lines have been crossed to Tg2576 ...

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...

Professional Information ProfessorCentre de Neurologie Cognitive - CMRR Paris Nord Comments Without ApoE3 or ApoE4, Alzheimer’s Would be a Rare Disease 23 Jan 2026 ...

This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...