Objective Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is an inherited adrenal steroid synthesis ...

High Intensity Use (HIU) programmes offer targeted outpatient appointments to those attending emergency departments (EDs) at significantly higher rates than the general population. They are ...

The heart and lungs work closely to meet the tissues’ oxygen demands. If the balance between oxygen demand and supply becomes disturbed in critical illness, tissue hypoxia and cell death can rapidly ...

Charts are presented which give centile standards for boys' and girls' heights at ages 2 to 9 when parents' height is allowed for. Mid-parent height is used (i.e. the average of father's and mother's ...

AIM To determine the incidence of hypocalcaemia in critically ill children with meningococcal disease. METHODS In a prospective cohort study, 70 of 80 patients admitted consecutively with a clinical ...

Genetic mutations affecting proteins required for normal surfactant protein function are a rare cause of respiratory disease. The genes identified that cause respiratory disease are surfactant protein ...

Aim To examine ethnic and sex differences in the pattern of skeletal maturity from adolescence to adulthood using a novel longitudinal analysis technique (SuperImposition by Translation And Rotation ...

Aim This literature review seeks to establish whether sufficient evidence showing an additional benefit of continuous glucose monitoring (CGM) on diabetes outcomes compared to intermittent self ...

Aims Up to 2% of all pregnancies are conceived by in vitro fertilisation (IVF) in the UK. IVF methodologies include fresh and frozen-thawed embryo transfer. Neonates conceived by frozen-thawed IVF are ...

Introduction With approximately 50% of the drugs being prescribed off-label, the pediatric population is in need for an innovative approach to establish harmonized, best evidence-based dosing ...

Methods All children (under 16 year) who had a DMSA scan following UTI in 2007 (Jan-July) prior to the introduction of the NICE guidelines were identified, and compared with those undergoing DMSA ...

AIMS To evaluate the effects of discontinuing growth hormone (GH) treatment on energy expenditure and body composition, which might help predict those most likely to benefit from early reintroduction ...