The structure and function of synapses are highly heterogeneous, even among synapses formed on single neuron 1,2,3. At the same time, pre- and postsynaptic structures and functions are well ...
Figure 1: VAMP–GFP distribution in transfected hippocampal neurons. Axonal VAMP–GFP puncta fell into two categories based on their dynamics as observed in time-lapse experiments. Puncta in one class ...
Acetylcholine (AcCho) release from purely cholinergic Torpedo synaptosomes was evoked by K$^{+}$ depolarization in the presence of Ca$^{2+}$. Activation of muscarinic receptors, present in the ...
Midbrain dopamine neurons project densely to the striatum and form so-called dopamine synapses on medium spiny neurons (MSNs), principal neurons in the striatum. Because dopamine receptors are widely ...
A breakthrough study at the University of Queensland has discovered a hidden dangerous feature of the black mamba, one of the ...
Many studies link tau to synaptic dysfunction and memory loss in Alzheimer’s disease and other dementias. But how does tau do its dirty work? Most previous research focused on the harmful effects of ...
Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat. The study helps find a better drug target for the ...
Phosphorylation of α-synuclein at serine 129 has long been used as a marker of synucleinopathy—p-S129syn accumulates in Lewy bodies, after all. But does this modification have a physiological function ...
In the nervous system, electrical signals are sent down a nerve cell (neuron) to a synapse that transmit the electrical signal from one nerve cell to another. Their main purpose is to limit the ...
An electrical impulse cannot directly cross the gap so a different mechanism has to be used. Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent ...
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