Few procedures have gone through a decade of practice-changing clinical trials as impressive as thrombectomy for stroke. Beginning in 2015 with multiple trials showing a benefit with thrombectomy ...

Endovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect of EVT for occlusion of medium or distal vessels is unclear. We randomly assigned ...

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by F. Hoffmann–La Roche. Disclosure forms provided by the authors are ...

Whether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies to stroke due to medium-vessel occlusion is unclear. In a multicenter, prospective ...

Familial HLH is a success story in modern medicine. Initially a disease that was largely unknown and fatal, it is now understood on a molecular level and is curable. Moreover, HLH is an archetype ...

S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org). Evaluation for an infectious cause was negative, and computed tomography of the abdomen and pelvis did ...

The development of simple, reliable ultraviolet and visible spectrophotometers within the last ten years has made available an analytical tool of great versatility and power. The role played by ...

Wash the wound with saline and close the skin edges with sutures of your choice. In the video demonstration, we used a nonabsorbable 4-0 nylon. 9 Dress the arm and wrap it with a padding roll ...

2 The steering committee members and the sponsor vouch for the adherence of the trial to the protocol (available with the full text of this article at NEJM.org). All the authors vouch for the ...

The trial centers are listed in the Supplementary Appendix, available with the full text of this article at NEJM.org. Full details about the trial design, population, procedures, and statistical ...

A data sharing statement provided by the authors is available with the full text of this article at NEJM.org. Supported by three consecutive project grants (12/147, 16/078, and 20/140) from the ...

The protocol (available at NEJM.org) was approved by the relevant ethics committees at the participating sites. An independent data monitoring committee provided external oversight. The raw ...