Will causal variants have similar allele frequencies and disease risk in different populations? What factors will be the sources of differing results across groups? As the human genetics community ...

Epigenetic clocks that quantify rates of aging from DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), ...

New research uncovers how declining protein clearance mechanisms with age lead to Alzheimer’s, Parkinson’s, and other ...

Aims Clopidogrel is the most commonly prescribed thienopyridine as part of dual anti-platelet therapy for the treatment of ...

Candidate genetic variants included in a genetic risk algorithm may not meet standards of reasonable clinical efficacy in identifying opioid use disorder risk, according to a study published in JAMA ...

Sequins, a newly-funded start-up in the next generation sequencing (NGS) ecosystem, announced today the availability of their first commercial products – the Sequins Metagenomics Core Control and ...

Chromosomal inversions are an important class of genetic variation that link multiple alleles together into a single inherited block that can have important effects on fitness. To study the role of ...

International collaboration in genomic research is gaining momentum in African countries and is often supported by external ...

No Z or S α 1-AT homozygotes were detected. The expected normal population frequency of the S and Z allele are 8% and 4%, respectively; 95% confidence intervals based on these figures are 1 to 13% and ...

Background SLE is a systemic autoimmune disease with a large number of common risk gene variants, but several rare gene ...

Participants were asked about their diets every 2 to 4 years to assess how much red meat and unprocessed red meat they ate, with 9 frequency options ranging ... for people who do not carry the APOE e4 ...

We plotted 19 URAT1 SNPs, excluding SNPs of less than 1% allele frequency. From 19 SNPs, we selected eight SNPs as tagging SNPs with high LD (r 2 >0.8). The eight SNPs are rs11602903, rs7929627, ...