This work presents valuable new data on the role of D-Serine and how it competes with its stereoisomer L-Serine to influence metabolism. The work presents a variety of solid experimental data combined ...

Learn more about eLife assessments Scientific progress depends on reliable and reproducible results. Progress can be accelerated when data are shared and re-analyzed to address new questions. Current ...

The ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge, United Kingdom ...

GFP knockin mouse tissue and ultra-fresh synaptonerosomes indicate that the postsynaptic density is a not a conserved feature of glutamatergic synapses in the mouse brain.

Structural and computational approaches uncover the molecular basis for dimerization, open-closed conformational transitions, and the dynamic behavior of the human angiotensin-I converting enzyme ...

In this important work, the authors present a new transformer-based neural network designed to isolate and quantify higher-order epistasis in protein sequences. They provide solid evidence that higher ...

This manuscript reports valuable results on the role of MDC1 and Treacle in DSB repair in rDNA repeats. It has been previously established that MDC1 is replaced by Treacle as the main adaptor in the ...

The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.

A combination of cryogenic electron microscopy and molecular simulations has been used to study the structure and dynamics of an enzyme called ACE.

Stimulation of the A13 brain region restores motor function in Parkinson's disease mouse models by alleviating bradykinesia and akinesia.

The objects that migrants carry with them are tethers to the lives they have left behind.

To parse foreground and background sounds, the auditory cortex of humans and ferrets share a similar hierarchical organization, but the underlying computational mechanisms are fundamentally different.