Histone Modification Types and Effects As essential DNA organizing proteins within the nucleus, histones and their modification can influence chromatin structure and gene expression.

Histone modification is an epigenetic mechanism that enables fine-tuning of gene expression. Mutation or dysregulation of proteins associated with histone modification (called “writers,” “erasers,” ...

Recent advances in epigenetics research provide more clues as to why identical twins are different and offer ways to treat ...

Histone modifications, especially lysine acetylation, are linked to stress responses and antidepressant effects in depression. 11 Additionally, ncRNAs, including circRNAs, miRNAs, and lncRNAs ...

A new study has decoded how pea plants respond to salt stress through precise epigenetic reprogramming. Researchers created the first genome-wide map of four major histone modifications—H3K4me3 ...

Peptidyl-arginine deiminase 2 (PAD2) enzyme converts arginine amino acid residues in histone proteins into citrulline groups ...

Epigenetic modifications may contribute to the development and progression of cancer. We investigated whether epigenetic changes involving multiple histones influence prognosis of non–small-cell lung ...

New research from Kyushu University has revealed an unexpected novel function of the histone modification H3K4me3: stabilizing chromosomes and spindles in mature mouse oocytes.

Now, researchers from Kyushu University have demonstrated that the histone modification H3K4me3 in mature mouse oocytes is directly involved in chromosome and spindle stabilization and is crucial ...