Leveraging strategies, such as serial passage in alternative hosts and genetic engineering techniques, have generated highly attenuated VACV vaccine vectors by deleting specific viral genes, most ...

“Using viral vectors is expensive and resource intensive,” said Shy. “A major benefit of a nonviral approach to gene engineering is that we’re not as limited by cost, manufacturing ...

Gene therapy is defined as the treatment of disease by transfer of genetic material into cells, to prevent, treat and potentially even cure a disease. Gene therapies can work by several mechanisms: 1) ...

Lentiviral vectors are important gene delivery tools for cell and gene therapies, notably chimeric antigen receptor T-cell (CAR-T cell) therapies which have proven successful in treating a growing ...