Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The Arizona Cardinals were beaten 41-22 by the San Francisco 49ers on Sunday at State Farm Stadium. A lot of thing went wrong. However, moving the ball offensively wasn't one of the problems. They had a season-high 488 yards of offense. They outgained the 49ers 488 to 281 in yards.

Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The Arizona Cardinals were destroyed by the Seahawks last week but they have a chance to get back on track in Week 11, with the 49ers coming to town.

Brock Purdy's return went as well as the San Francisco 49ers could have hoped, as they routed the Arizona Cardinals on Sunday.

Rookie Mike linebacker Cody Simon, playing instead of the injured Mack Wilson Sr., safeties Budda Baker and Jalen Thompson, and cornerback Max Melton played every snap. Rookie cornerback Denzel Burke missed six.

The San Francisco 49ers defeated the Arizona Cardinals on Sunday. Here's who had the best and worst days, according to Pro Football Focus.

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Eddy Piñeiro nears return, adding WR Javon Baker while releasing Matt Gay and Adrian Martinez to reshape depth.