RNA therapeutics target translation rather than DNA, aiming to correct shared protein production errors. By enabling cells to read through premature stop codons, engineered tRNAs could restore ...

For disorders driven by a known genetic component, research understandably focuses on developing a drug targeting that genetic signature. When that works, the outcome benefits patients but the end ...

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

Transfer RNAs (tRNAs) deliver specific amino acids to ribosomes during translation of messenger RNA into proteins. The abundance of tRNAs can therefore have a profound impact on cell physiology, but ...

A research paper published in the journal Cell Metabolism by the team of Prof. Liu Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate tRNA ...

There are different kinds of ribonucleic acids that play essential roles in many aspects of molecular biology, including the creation of proteins from gene sequences in DNA. One type of ribonucleic ...

A new advanced, high-throughput sequencing technique should enable scientists to have a firmer grasp on the activity of naturally occurring microbiomes in response to real-world conditions and diet.

The various identities of cells, whether they are in the brain, heart, kidney, or any other tissue, are defined by the genes they expressed. In basic terms, the genes that are active in a cell are ...

A novel tRNA fragment limits UV-driven photoageing by protecting collagen and mRNA stability. Discover the mechanism and its therapeutic potential. Read more.

A groundbreaking study has shed light on the critical role of a tRNA methylation enzyme, TRMT10A, in supporting brain function. The findings reveal how the absence of TRMT10A leads to a reduction in ...