At the heart of Toti-N-Seq lies an engineered protein, Stv-Fg, derived from modifying the natural glycan-binding protein Fbs1. This fusion protein binds non-selectively to all N-glycan types, enabling ...

Using single-nuclei RNA sequencing (snRNA-seq), scientists from Mass General Brigham, SUNY Upstate Medical University, and elsewhere have identified specific brain cell types in the hippocampus that ...

The intestine is the most critical digestive organ and the largest immune organ in mammals, playing a central role in nutrient absorption, endocrine secretion, and defense against microorganisms.

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer's disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical ...

How do astrocytes react to Alzheimer’s disease pathology? It’s complicated, according to the largest single-nuclei RNA-Seq study of these cells published thus far. Scientists led by Sudeshna Das at ...