An important goal in drug development is to engineer inhibitors and ligands that have high binding affinities for their target molecules. In optimizing these interactions, the precise determination of ...

Isothermal titration calorimetry (ITC) is an analytical technique, which is often thought of as the gold standard for analyzing intermolecular interactions. It is a titrimetric method, which is a ...

Biochemical reactions are regulated by enzymes. These reactions involve binding, recognition, and the creation of non-covalent complexes. It is essential to characterize binding events in order to ...

All biochemical reactions involve recognition, binding, and the formation of noncovalent complexes. Many small molecule drugs act by selectively binding to protein or nucleic acid targets and altering ...

Complexes, such as protein/protein, nucleic acids/nucleic acid, protein/nucleic acid, protein/ligand, nucleic acid/ligand, are often difficult to crystallize even on well-defined biological systems, ...