Medical University of South Carolina (MUSC) investigators report that long-term expansion protocols for adoptive cancer immunotherapy do not compromise Th17 cells' effectiveness against large tumors, ...

An international study group led by researchers from Osaka University identifies a protein regulator responsible for inducing the pathogenic properties of Th17 cells, leading to multiple sclerosis and ...

Th17 cells are abundant in multiple chronic inflammatory and autoimmune diseases. Clinical trials with antibodies to interleukin (IL)-17A, one of the Th17-cell signature cytokines, have recently ...

Of note, the authors found that both TGF-β3 and TGF-β1 signal through the same receptor (TGF-βRII) for Th17 differentiation, suggesting that TGF-β3 and TGF-β1 deliver differential downstream signaling ...

The gut is home to a cast of microbes that influence health and disease. Some types of microorganisms are thought to contribute to the development of inflammatory conditions, such as inflammatory ...

Biomarkers to predict immune-related adverse events with checkpoint inhibitors. This is an ASCO Meeting Abstract from the 2019 ASCO-SITC Clinical Immuno-Oncology Symposium. This abstract does not ...

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such ...

The cytokine profile (including key cytokine receptors as denoted by R), the effector cell type that is activated, and the corresponding types of infections are shown for each Th subgroup. The ...

Scientists from the Icahn School of Medicine at Mount Sinai (MSSM) have published a study that describes the biological mechanism used by a family of proteins called histone deacetylases to activate ...

Introduction: Inflammation plays a pivotal role in blood pressure regulation. Data on experimental models of hypertension and hypertensive patients reflect the imbalance between T regulatory (Treg) ...

Assessment of chemotherapy-induced nausea and vomiting in adult patients with hematopoietic stem-cell transplant at a tertiary care hospital. This is an ASCO Meeting Abstract from the 2024 ASCO Annual ...

Multiple sclerosis (MS) and other inflammatory autoimmune diseases are characterized by localized inflammation in various tissues, including the brain. Using a mouse model of MS, a team has identified ...