The field of neurotrauma and epilepsy research has increasingly highlighted the pivotal influence of ion channels in the transition from traumatic brain ...

Inwardly rectifying potassium (Kir) channels are gated by the membrane phospholipid phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P 2). Among them, Kir3 requires additional molecules, such as the ...

Scientists now have a better picture of how voltage-gated sodium (Na v) channels interact with certain animal toxins, thanks to structures solved with cryo-electron microscopy. These channels are ...

Nat Clin Pract Neurol. 2008;4(3):159-169. Drug Primary clinical use Protective effect during administration in animal models? Effects of withdrawal in EAE Clinical study Phenytoin Treatment of ...

Inhibitory postsynaptic potentials (IPSPs) in neocortical pyramidal neurons are increased in duration and amplitude at depolarized membrane potentials. This effect was not due to changes in the time ...

Neurobiologist John Wood has long been interested in how animals feel pain. His research at University College London (UCL) typically involved knocking out various ion channels important in sensory ...

A novel, investigational NaV1.8 sodium channel blocker known as VX-548 reduced acute pain after abdominoplasty or bunionectomy at the highest dose, but not at lower doses, two phase II trials showed.

Ion selectivity is an important property of cell membrane ion channels. For example, potassium ion channels are more permeable to potassium ions than to sodium ions. The mechanism underlying the ready ...

Note: On January 30, 2025 the FDA approved the first-in-class non-opioid analgesic Journavx (suzetrigine) for the treatment of moderate to severe acute pain in adults. The novel drug reduces pain by ...