Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a ...

The envelope protein from SARS-CoV-2 (E) is a single pass transmembrane protein which accumulates in the endoplasmic reticulum golgi intermediate compartment in host cells, where it acts as a ...

The global pandemic may be over, but SARS-CoV-2 continues to infect people around the world. Indeed, the United States has recorded roughly 750 deaths from COVID-19 over the past month. Now, an siRNA ...

UCSF researchers designed new drug candidates that potently block MPro, a viral enzyme that's crucial for SARS-CoV-2 replication. One of these drug candidates, AVI-4516, is shown (center) bound to the ...

In a recent study published in the Journal of Experimental Medicine, researchers identified the cellular tropism and transcriptome consequences of severe acute respiratory syndrome coronavirus 2 (SARS ...

Six years after the COVID-19 pandemic, which had claimed over 7 million lives worldwide by April 2024 (figures are no longer being tracked), we are still debating the origins of this novel virus. The ...

Two of the closest known relatives to SARS-CoV-2 — a pair of bat coronaviruses discovered by researchers in Laos — may transmit poorly in people despite being genetically similar to the ...

In a recent preprint* study posted to the bioRxiv server, a team of researchers analyzed the virological characteristics and epidemiological impact of the Severe Acute Respiratory Syndrome Coronavirus ...

Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a protein and alter its function. A team at HZB has now investigated the Nsp1 ...