In a retrospective study at Dutch hospitals, dosing irinotecan based on UGT1A1 genotype normalized the risk of severe toxicity and hospitalization in patients who were poor metabolizers of the drug.
Most antidepressants are metabolized through the cytochrome P (CYP) 450 pathway; therefore, most drug metabolism genes on pharmacogenetic testing panels are related to CYP450 oxidase enzyme subunits.
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