Decades of slow-moving research, along with broader failures of the healthcare system, have left millions of people in daily ...

Pacira BioSciences’ CEO discusses research into pain treatment that has less chance of creating dependency and addiction ...

A recent clinical trial found that adjunctive dexmedetomidine didn't significantly improve pain scores or reduce opioid consumption in ICU patients with traumatic rib fractures.

Nitazenes—a class of highly potent synthetic opioids—are rapidly emerging as a major contributor to the overdose crisis, ...

Endogenous opioid peptides are the neurochemical basis of the anesthetic and analgesic effects of acupuncture. The quantity of acupuncture stimulus can be controlled accurately by using ...

Research findings suggest opioids, with varying efficacy at the μ and κ receptors, produce independent effects on unique pain mechanisms and individual responsiveness for some is dependent on pain ...

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...

Most people who misuse opioids take the drugs to relieve pain, but data suggest that men are more likely to misuse and overdose on opioids than women, even though they suffer less chronic pain.

There is a time for everything. Now is the time for the Department of Veterans Affairs to go opioid-free. When I first began practicing medicine at the VA, it was common to “prescribe” alcoholic ...