In dry granulation, powders bind because of the application of mechanical stress. As particles are forced to be within closer proximity, entrained air is forced out, bulk density increases, and a ...

Wet granulation is the most widely-used technology for granulation, even though it consists of many steps and product transfer, which increases production costs. It is the most flexible granulation ...

Adopting a Quality by Design (QbD) approach for wet granulation requires manufacturers to comprehend the correlation between process variables, such as powder characteristics and equipment ...

Granulation is a critical unit operation in pharmaceutical manufacturing, where fine powders are agglomerated into granules to improve flow properties, uniformity, and compaction performance. The ...

Granulation is important in the pharmaceutical industry because of increased pressures due to the costs of manufacturing solid dosage forms. Granulation forms coarser collections from fine powder.

A twin-screw extruder can be used as a continuous wet granulator or as a continuous mixer for a wet gelatin mass. Twin-screw extruders, which have found commercial use in making amorphous ...