GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

Purdue University scientists are deciphering an intricate cellular signaling system critical to immune response to better understand how it could be used to address multiple diseases, including cancer ...

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...

Taste, pain, or response to stress — nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers at the University of ...

Researchers used AlphaFold3, the latest AI-based protein modeling system, to predict the structures of all 25 known human ...

A new study found that a single mutation to the hemagglutinin protein of an H5N1 virus isolated from a dairy worker in Texas this spring switched the protein’s binding specificity from avian- to human ...

In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new ...