GPCRs are the largest receptor class, affecting almost every aspect of human physiology, with 35% of all approved drugs acting on GPCRs. They regulate sensory and neuronal signaling, as well as a ...

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

Lefkowitz started to trace cell receptors in 1968. Using radioactivity, he managed to unveil several receptors, including one for adrenalin, the β-adrenergic receptor. His team then extracted the ...

Purdue University scientists are deciphering an intricate cellular signaling system critical to immune response to better understand how it could be used to address multiple diseases, including cancer ...

Researchers used AlphaFold3, the latest AI-based protein modeling system, to predict the structures of all 25 known human ...

AbbVie is paying $255 million cash to acquire British biotech DJS Antibodies and its platform for targeting transmembrane proteins. DJS is focused on difficult-to-drug disease-causing proteins, such ...

A new study found that a single mutation to the hemagglutinin protein of an H5N1 virus isolated from a dairy worker in Texas this spring switched the protein’s binding specificity from avian- to human ...

In the march of metastasis, a molecular trail of crumbs guides some cancer cells from the primary tumor to establish new ...