Alpha-substituted fatty amines and nitrogen-containing heterocycles are widely found in numerous bioactive natural products, pharmaceutical molecules, and agrochemicals. A recent analysis of small ...

Even though amide bonds are everywhere—they hold proteins together and are essential components in many drugs—forging this molecular motif in a reaction flask can be challenging. For example, making ...

Esters are common in nature and have found widespread applications in industry 1. In nature, esters are responsible for the aroma of many flowers and fruits, and fats are generally triesters. In ...

Medicines come from chemical reactions, and better chemical reactions lead to better medicines. Yet, the most popular reaction used in drug discovery, called the amide coupling, makes an inherently ...

Amide bonds are among the most ubiquitous linkages in natural products, pharmaceuticals and polymers, yet their inherent resonance stabilisation renders them remarkably inert to conventional reaction ...