A collaborative research team has uncovered a previously unknown mechanism of action of yaku'amide B, a structurally complex peptidic natural product derived from deep-sea sponge found in the waters ...

A team of scientists headed by Rosalind Franklin University Professor David M. Mueller, PhD, has solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, ...

Found inside mitochondria, ATP synthase generates the energy storage molecule adenosine triphosphate, which the cells of all living things use for fuel. The enzyme generally looks similar in shape ...

In 2005, a class of compound was discovered that could inhibit the bacterium that causes tuberculosis infections in humans — Mycobacterium tuberculosis 1. Unexpectedly, the target of these drugs was ...

Rotary ATPases are ubiquitous membrane-bound macromolecular enzymes with similar architecture and mechanism but two distinct physiological functions. All rotary ATPases consist of a transmembrane ...

Mitochondrial dysfunction, including decreased mitochondrial respiration and increased mitochondrial stress, is associated with many major human diseases and casual to many pathological defects.

Mitochondria, the major energy source for most cells, also play an important role in stem cell development — a purpose notably distinct from the tiny organelle’s traditional job as the cell’s main ...

Oncotarget recently published "Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis" by Kim, et al. which reported that the authors show that CADD522 inhibits ...

The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has ...