Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The NFC West has turned into a three-headed monster this season with the Los Angeles Rams, Seattle Seahawks and San Francisco 49ers winning boatloads of games and fighting for first place. Then there's the sorry state of the Arizona Cardinals.

The San Francisco 49ers notched a fairly impressive, and expected, win against the Arizona Cardinals. It was a nice rebound after getting throttled last week. P

The Arizona Cardinals were destroyed by the Seahawks last week but they have a chance to get back on track in Week 11, with the 49ers coming to town.

Find single game tickets to the San Francisco 49ers vs. Arizona Cardinals NFL Week 11 matchup on Sunday, November 16, 2025 at State Farm Stadium.

San Francisco gets to No. 6 no matter how this game finishes. The 49ers would move ahead of the 8-4-1 Packers if Chicago wins. They'd jump over the No. 7 seed 9-4 Bears to No. 6 if Green Bay wins. A loss from one of the Seahawks or Rams would push the 49ers up to No. 5, ahead of the NFC West team that lost and ahead of the loser of Packers-Bears.

How Week 14 games impact San Francisco's NFC seeding, postseason path, and key rooting interests in a tight playoff race.

While the 49ers might not be as well represented as years past at the 2026 NFL Pro Bowl Games, San Francisco still has a couple of notable players who currently are earning a large portion of fan voting.